Designated as WOAH Reference Laboratory for Brucellosis at 77th WOAH general session in May, 2009.
Dr. Jin-Ju Lee
[Animal and Plant Quarantine Agency]
Bacterial Disease Division
[Animal and Plant Quarantine Agency]
Antimicrobial susceptibility of Brucella canis isolates from dogs in Korea(2012-01-10) | |||||
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Part | Animal and Plant Health Research | Charger | Moon Her | date | 2012-01-10 |
Eun-Jeong Heo, Jong-Wan Kim, Dong-Hee Cho, Hyang-Mi Nam, Yun-Sang Cho, In-Yeong Hwang, Suk-Chan Jung, Sung-Hwan Wee and Hee-Soo Lee*. 2009. Antimicrobial susceptibility of Brucella canis isolates from dogs in Korea. Korean. J. Vet. Publ. Hlth. 33, 213-219 Abstract Brucella canis is the causative agent of brucellosis in dogs, which causes contagious abortion. This pathogen was recognized as an important economic problem in dog breeding kennels. B. canis infection in human has also been reported, suggesting that this bacteria can cause public health problems. A total of 276 B. canis were isolated from house dogs and farm dogs having suspected canine brucellosis during 1994-2006 in Korea. Of those isolates, 40 were randomly selected by year and evaluated for antimicrobial resistance using minimal inhibitory concentrations (MICs). All the isolates examined were highly susceptible to tetracyclines and aminoglycosides, and the MICs of these drugs ranged from 0.063 to 1 ㎍/mL. Fluoroquinolones also showed effective activities with MICs ranged from 0.063 to 2 ㎍/mL. However, trimethoprim, cephalothin, and sulfamethazine were found to be less effective against all the isolates tested. The MICs of these three antibiotics ranged from 16 to >32 1 ㎍/mL. Of three macrolide antibiotics tested, erythromycin was the most effective against B. canis isolates, compared to tylosin and spiramycin. Rifampin and chloramphenicol showed intermediate activities against the isolates. The choice of antibiotics in this study focused on in vivo application to animals and humans. This study indicates that tetracyclines, aminoglycosides and fluoroquinolones are the most effective against B. canis isolated from dogs in Korea. |
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