Pathological Features of Quails Naturally Infected With H5N1 Highly Pathogenic Avian Influenza Virus During 2006/2007 Epidemic in South Korea ( 07/06/27 ) | |||||
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Part | Charger | mckim00 | date | 07/06/27 | |
Poster presentation in the Korean Society of Veterinary Science on April 20, 2007.
Results and conclusion
Results:
On 11 December 2006, the first HPAI case was diagnosed in the quail farm located at the southern part of Korea,
Jeonbuk province. The farm consisted of three houses — house A (65,000 7-month-old and 65,000 4-month-old flocks),
house B (100,700 45-day-old flock) and house C (65,000 2-day-old flock) — but the clinical sign was found in only
4-month-old flock. Increased mortality was first observed on December 8 and cumulative mortality in the flock was 5.4%
before submitted to the National Veterinary Research and Quarantine Service. On gross findings, there was redness of
pancreas, enlargement of spleen, catarrhal to hemorrhagic luminal exudates in oviduct and hemorrhages
on the epicardium. Histopathologic lesions were mainly seen in the oviduct, brain, intestine, pancreas, heart and lung.
These lesions consisted of necrosis of epithelial cell in oviduct, meningoencephalitis, enteritis, necrosis of acinar epithelium in pancreas, necrosis of cardiac myocyte and interstitial pneumonia. Immunohistochemically,
influenza virus antigens were mainly observed in the epithelium of oviduct, serosal membrane of intestine, ependymal
cell and choroids epithelium in brain, macrophages and ellipsoid capillary endothelium in spleen and macrophage of
air capillary wall in lung. Interestingly, there was no lesion and antigen in the vascular endothelium, which is different
from those of chicken. There was a relationship between the locations of viral antigens and histological lesions but all
the histopathologic lesions were not accord to the immunohistochemical stains in the same tissues.
Conclusions:
This outbreak of HPAI in quail was the first case in Korea. There was no specific common gross lesion. The virus was distributed in the internal organ but not in vascular endothelium, which is clearly different from chicken cases.
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